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Greater estrogen ranges linked to decrease COVID loss of life danger; antacid reveals promise addressing signs

Higher estrogen levels linked to lower COVID death risk; antacid shows promise addressing symptoms

FILE PHOTO: A healthcare employee takes a swab pattern from a girl to check for the brand new coronavirus illness (COVID-19) at a COVID-19 testing middle in Brussels, Belgium, January 27, 2022. REUTERS/Yves Herman

A brand new research strengthens suspicions that the feminine hormone estrogen protects towards loss of life from COVID-19.

Researchers in Sweden studied 14,685 older ladies with COVID-19, all of whom have been previous menopause, throughout which estrogen ranges decline dramatically. Seventeen % have been taking estrogen dietary supplements to alleviate menopausal signs.

After adjusting for different danger elements, ladies getting further estrogen had a 53 % decrease danger of dying from COVID-19 in comparison with untreated ladies, the researchers reported on Monday in BMJ Open.

Observational research comparable to this one can not show greater estrogen ranges are protecting. Moreover, the ladies have been contaminated earlier than vaccines have been out there, stated Dr. Malin Sund of Umea College.

“Vaccination has clearly been proven to guard from COVID-19 associated mortality and the potential added worth from estrogen (in vaccinated ladies) can’t be estimated from this information,” Sund stated.

The concept estrogen could be protecting in hospitalized COVID-19 sufferers is now being examined extra rigorously in a randomized managed trial at Tulane College.

In one other growth, a randomized managed trial signifies that antacid reveals promise towards COVID-19 signs.

In non-hospitalized, unvaccinated adults with mild-to-moderate COVID-19, therapy with a excessive dose of the antacid drug famotidine helped velocity decision of signs and irritation in a small randomized managed trial.

Roughly half of these within the 55-patient trial took famotidine – the primary ingredient in Johnson & Johnson’s extensively used over-the-counter Pepsid heartburn drug – thrice a day for 2 weeks. The others took a dummy tablet.

Sufferers within the famotidine group had quicker decision of 14 of 16 signs assessed within the research, together with lack of odor and style, issue respiration, and belly ache. Famotidine therapy additionally led to quicker enhancements in markers of irritation with none detrimental results on sufferers’ immune responses, the researchers reported within the journal Intestine. A few third of the research’s contributors have been Black and 1 / 4 Hispanic.

“We hope that the information we’re sharing with this research information future trials which are crucial to verify famotidine as a therapy for sufferers with COVID-19,” research chief Dr. Tobias Janowitz of Northwell Well being and Chilly Spring Harbor Laboratory stated in a information launch.


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